intestinal perforation in a patient with paroxysmal nocturnal hemoglobinuria

نویسندگان

reza kayat birjand university of medical sciencesgeneral surgeon ,emam reza hospital, birjand, iran

elahe bijari birjand university of medical sciencesstudent research committee, faculty of medicine, birjand university of medical sciences birjand, iran

چکیده

paroxysmal nocturnal hemoglobinuria (pnh) is a rare hematologic disorder that manifests with hemolytic anemia, thrombosis, and peripheral blood cytopenias.acute abdominal pain is one of the pnh clinical manifestations due to venous thrombosis of intra-abdominal sites including hepatic, portal, mesenteric, and splenic veins.eculizumaband allogeneic bone marrow transplantation (bmt) arethe only widely effective therapies for these patients. we report a case of pnh disorder which presented with abdominal pain and mild tenderness. abdominal x ray and sonography revealed intra-peritonealfree fluid and air. at laparotomy, an ischemic segment of jejunum with stricture and perforationwith mesenteric venous thrombosis were found. the patient also had a history of hepatic vein thrombosis two years before.

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Intestinal perforation in a patient with paroxysmal nocturnal hemoglobinuria

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surgery and trauma

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